| pubmed-article:7597103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7597103 | lifeskim:mentions | umls-concept:C0035366 | lld:lifeskim |
| pubmed-article:7597103 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:7597103 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:7597103 | lifeskim:mentions | umls-concept:C0023907 | lld:lifeskim |
| pubmed-article:7597103 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:7597103 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7597103 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:7597103 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:7597103 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:7597103 | pubmed:dateCreated | 1995-8-3 | lld:pubmed |
| pubmed-article:7597103 | pubmed:abstractText | Retrovirus-mediated gene transfer into hepatocytes in vivo results in long-term gene expression. Limitations include the need to remove two-thirds of the liver and the relatively low frequency of gene transfer. To increase gene transfer without surgical hepatectomy, mouse hepatocytes were transduced in vivo with a recombinant adenovirus that transiently expressed urokinase, resulting in high rates of asynchronous liver regeneration. During the regenerative phase, in vivo retroviral-mediated gene transfer in hepatocytes resulted in 5- to 10-fold greater transduction efficiencies than that obtained by conventional partial hepatectomy. In 3-4 weeks, the architecture and microscopic structure of the recipient livers were normal. The two-viral system of achieving permanent transgene expression from hepatocytes in vivo offers an alternative approach to current ex vivo and in vivo gene-transfer models. | lld:pubmed |
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| pubmed-article:7597103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7597103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7597103 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7597103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7597103 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7597103 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7597103 | pubmed:author | pubmed-author:KayM AMA | lld:pubmed |
| pubmed-article:7597103 | pubmed:author | pubmed-author:FaustoNN | lld:pubmed |
| pubmed-article:7597103 | pubmed:author | pubmed-author:PerkinsJJ | lld:pubmed |
| pubmed-article:7597103 | pubmed:author | pubmed-author:LieberAA | lld:pubmed |
| pubmed-article:7597103 | pubmed:author | pubmed-author:MeuseLL | lld:pubmed |
| pubmed-article:7597103 | pubmed:author | pubmed-author:Vrancken... | lld:pubmed |
| pubmed-article:7597103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7597103 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:7597103 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7597103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7597103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7597103 | pubmed:pagination | 6210-4 | lld:pubmed |
| pubmed-article:7597103 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7597103 | pubmed:meshHeading | pubmed-meshheading:7597103-... | lld:pubmed |
| pubmed-article:7597103 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7597103 | pubmed:articleTitle | Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo. | lld:pubmed |
| pubmed-article:7597103 | pubmed:affiliation | Markey Molecular Medicine Center, Department of Medicine, University of Washington, Seattle 98195, USA. | lld:pubmed |
| pubmed-article:7597103 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7597103 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7597103 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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