Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5 Pt 1
|
| pubmed:dateCreated |
1995-12-6
|
| pubmed:abstractText |
Polymorphonuclear leukocytes (PMN) are the predominant inflammatory cells recruited in acute lung injury. This study compares the concentration of interleukin-8 (IL-8) to those of GRO alpha, both of which are CXC chemokines, in bronchoalveolar lavage fluid (BALF) in three acute pathologic states: bacterial pneumonia (BPN); adult respiratory distress syndrome (ARDS); and Pneumocystis carinii pneumonia (PCP). Levels of both IL-8 and GRO alpha were below 5 pg/ml in 16 nonsmoking volunteers who served as controls. Despite more than twice as many neutrophils in the BALF of the BPN group (n = 12) than in the group with ARDS (n = 13), both groups had similar levels of IL-8, of 569 +/- 120 pg/ml and 507 +/- 96 pg/ml, respectively. The GRO alpha concentrations in the BPN and ARDS patients were respectively 3.3 and 3.4 times those of IL-8, reaching 1,870 +/- 314 pg/ml for the BPN and 1,699 +/- 377 for the ARDS patients. In the PCP group (n = 48, 45 human immunodeficiency virus [HIV]-positive, 3 HIV-negative), GRO alpha levels (897 +/- 172 pg/ml) were sevenfold higher than IL-8 levels (123 +/- 40 pg/ml). In all pathologic states there was a good correlation between GRO alpha and IL-8 (r = 0.53, p = 0.0001). GRO alpha or IL-8 both correlate with the absolute neutrophil number/ml when all groups were studied together (r = 0.52, p = 0.0001). Only in the PCP and ARDS groups did IL-8 correlate with the PMN number.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
152
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1549-54
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7582292-AIDS-Related Opportunistic Infections,
pubmed-meshheading:7582292-Adolescent,
pubmed-meshheading:7582292-Adult,
pubmed-meshheading:7582292-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:7582292-Bronchopneumonia,
pubmed-meshheading:7582292-Chemokine CXCL1,
pubmed-meshheading:7582292-Chemokines,
pubmed-meshheading:7582292-Chemokines, CXC,
pubmed-meshheading:7582292-Chemotactic Factors,
pubmed-meshheading:7582292-Chemotaxis, Leukocyte,
pubmed-meshheading:7582292-Growth Substances,
pubmed-meshheading:7582292-HIV-1,
pubmed-meshheading:7582292-Humans,
pubmed-meshheading:7582292-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:7582292-Interleukin-8,
pubmed-meshheading:7582292-Male,
pubmed-meshheading:7582292-Neutrophils,
pubmed-meshheading:7582292-Pneumonia, Bacterial,
pubmed-meshheading:7582292-Pneumonia, Pneumocystis,
pubmed-meshheading:7582292-Respiratory Distress Syndrome, Adult,
pubmed-meshheading:7582292-Statistics, Nonparametric
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
GRO alpha and interleukin-8 in Pneumocystis carinii or bacterial pneumonia and adult respiratory distress syndrome.
|
| pubmed:affiliation |
Department of Medicine, Hôpital Cantonal Universitaire, Geneva, Switzerland.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|