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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5231
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pubmed:dateCreated |
1995-10-25
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pubmed:abstractText |
Activation of early response genes by interferons (IFNs) requires tyrosine phosphorylation of STAT (signal transducers and activators of transcription) proteins. It was found that the serine-threonine kinase mitogen-activated protein kinase (MAPK) [specifically, the 42-kilodalton MAPK or extracellular signal-regulated kinase 2 (ERK2)] interacted with the alpha subunit of IFN-alpha/beta receptor in vitro and in vivo. Treatment of cells with IFN-beta induced tyrosine phosphorylation and activation of MAPK and caused MAPK and Stat1 alpha to coimmunoprecipitate. Furthermore, expression of dominant negative MAPK inhibited IFN-beta-induced transcription. Therefore, MAPK appears to regulate IFN-alpha and IFN-beta activation of early response genes by modifying the Jak-STAT signaling cascade.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Interferon alpha-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
269
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1721-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7569900-Binding Sites,
pubmed-meshheading:7569900-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:7569900-Cells, Cultured,
pubmed-meshheading:7569900-DNA-Binding Proteins,
pubmed-meshheading:7569900-Enzyme Activation,
pubmed-meshheading:7569900-Gene Expression Regulation,
pubmed-meshheading:7569900-Humans,
pubmed-meshheading:7569900-Interferon-alpha,
pubmed-meshheading:7569900-Interferon-beta,
pubmed-meshheading:7569900-Membrane Proteins,
pubmed-meshheading:7569900-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:7569900-Phosphorylation,
pubmed-meshheading:7569900-Receptor, Interferon alpha-beta,
pubmed-meshheading:7569900-Receptors, Interferon,
pubmed-meshheading:7569900-Recombinant Fusion Proteins,
pubmed-meshheading:7569900-STAT1 Transcription Factor,
pubmed-meshheading:7569900-Signal Transduction,
pubmed-meshheading:7569900-Trans-Activators,
pubmed-meshheading:7569900-Transcription, Genetic,
pubmed-meshheading:7569900-Transfection,
pubmed-meshheading:7569900-Tumor Cells, Cultured,
pubmed-meshheading:7569900-Tyrosine
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pubmed:year |
1995
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pubmed:articleTitle |
Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins.
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pubmed:affiliation |
Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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