Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1995-11-14
pubmed:abstractText
In this paper we report a recessive mutation, immune deficiency (imd), that impairs the inducibility of all genes encoding antibacterial peptides during the immune response of Drosophila. When challenged with bacteria, flies carrying this mutation show a lower survival rate than wild-type flies. We also report that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in a homozygous imd mutant background. These results point to the existence of two different pathways leading to the expression of two types of target genes, encoding either the antibacterial peptides or the antifungal peptide drosomycin.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-1373375, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-1740152, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-1852009, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-2104802, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-2125051, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-6087289, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-6312420, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-7505569, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-7772280, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-7806546, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-7813433, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-7849506, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-7859742, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-8062131, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-8168509, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-8242747, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-8325867, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-8337755, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-8345514, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568155-8467806
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9465-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7568155-Animals, pubmed-meshheading:7568155-Anti-Bacterial Agents, pubmed-meshheading:7568155-Antimicrobial Cationic Peptides, pubmed-meshheading:7568155-Bacterial Infections, pubmed-meshheading:7568155-Base Sequence, pubmed-meshheading:7568155-Drosophila, pubmed-meshheading:7568155-Drosophila Proteins, pubmed-meshheading:7568155-Gene Expression Regulation, pubmed-meshheading:7568155-Genes, Insect, pubmed-meshheading:7568155-Genes, Recessive, pubmed-meshheading:7568155-Genes, Reporter, pubmed-meshheading:7568155-Glycopeptides, pubmed-meshheading:7568155-Insect Hormones, pubmed-meshheading:7568155-Insect Proteins, pubmed-meshheading:7568155-Male, pubmed-meshheading:7568155-Molecular Sequence Data, pubmed-meshheading:7568155-Mutation, pubmed-meshheading:7568155-Mycoses, pubmed-meshheading:7568155-Peptides, pubmed-meshheading:7568155-Protein Binding, pubmed-meshheading:7568155-Regulatory Sequences, Nucleic Acid, pubmed-meshheading:7568155-Survival Analysis
pubmed:year
1995
pubmed:articleTitle
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
pubmed:affiliation
Institut de Biologie Moléculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, Strasbourg, France.
pubmed:publicationType
Journal Article, Comparative Study