|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0031760,
umls-concept:C0035322,
umls-concept:C0042900,
umls-concept:C0055966,
umls-concept:C0162638,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C1413514,
umls-concept:C1518263,
umls-concept:C2827446,
umls-concept:C2911684
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1995-11-6
|
|
pubmed:abstractText |
To determine the mechanism of photoreceptor cell death in the vitiligo mouse, a model of retinal degeneration in which the genetic defect is not retina specific but is instead caused by single point mutation in the microphthalmia (mi) gene that codes for a basic helix-loop-helix DNA transcription factor.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0146-0404
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
36
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2193-201
|
|
pubmed:dateRevised |
2010-3-24
|
|
pubmed:meshHeading |
pubmed-meshheading:7558712-Aging,
pubmed-meshheading:7558712-Animals,
pubmed-meshheading:7558712-Apoptosis,
pubmed-meshheading:7558712-Cell Death,
pubmed-meshheading:7558712-Clusterin,
pubmed-meshheading:7558712-Complement Inactivator Proteins,
pubmed-meshheading:7558712-DNA Damage,
pubmed-meshheading:7558712-Glycoproteins,
pubmed-meshheading:7558712-In Situ Hybridization, Fluorescence,
pubmed-meshheading:7558712-Mice,
pubmed-meshheading:7558712-Mice, Inbred C57BL,
pubmed-meshheading:7558712-Mice, Mutant Strains,
pubmed-meshheading:7558712-Microphthalmos,
pubmed-meshheading:7558712-Molecular Chaperones,
pubmed-meshheading:7558712-Nerve Tissue Proteins,
pubmed-meshheading:7558712-Nucleotide Mapping,
pubmed-meshheading:7558712-Photoreceptor Cells,
pubmed-meshheading:7558712-Pigment Epithelium of Eye,
pubmed-meshheading:7558712-RNA, Messenger,
pubmed-meshheading:7558712-Retina,
pubmed-meshheading:7558712-Retinal Degeneration,
pubmed-meshheading:7558712-Vitiligo
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium.
|
|
pubmed:affiliation |
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912-2000, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
