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rdf:type |
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lifeskim:mentions |
umls-concept:C0002844,
umls-concept:C0017262,
umls-concept:C0017710,
umls-concept:C0021760,
umls-concept:C0052193,
umls-concept:C0185117,
umls-concept:C0441472,
umls-concept:C0600251,
umls-concept:C1418587,
umls-concept:C1512505,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
1995-11-3
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pubmed:abstractText |
Our study was designed to investigate the potential interaction between steroid hormones and interleukin-6 (IL-6) in the regulation of apolipoprotein D (apo-D) and gross cystic disease fluid protein 15 (GCDFP-15) expression in ZR-75-1 human breast cancer cells. We first observed that exposure to IL-6 for 6-14 days decreased basal apo-D and GCDFP-15 secretion by 50% and 23%, respectively. In the same experiment, such treatment with IL-6 decreased cell proliferation by approximately 40% after 6 and 14 days of incubation. Exposure to IL-6 markedly decreased dihydrotestosterone (DHT)-induced apo-D and GCDFP-15 release, with a half-maximal effect measured at 13 U/ml. A similar inhibitory action of IL-6 was observed on the glucocorticoid dexamethasone (DEX)-induced apo-D and GC-DFP-15 secretion. The sensitivity of the apo-D and GCDFP-15 response to the stimulatory action of DHT or DEX was, however, not changed by concomitant exposure to IL-6. The inhibitory effect of IL-6 on the secretion of these two biochemical markers was additive to that of 17 beta-estradiol. In addition, IL-6 blocked the stimulatory effect of interleukin-1 alpha (IL-1 alpha) on apo-D and GCDFP-15 secretion. Our results show that IL-6 is a potent inhibitory of basal as well as androgen-, glucocorticoid- and IL-1 alpha-induced apo-D and GCDFP-15 secretion in ZR-75-1 human breast cancer cells, while cell proliferation is inhibited by this cytokine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APOD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Androgens,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins D,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydrotestosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PIP protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
732-7
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:7558422-Androgens,
pubmed-meshheading:7558422-Apolipoproteins,
pubmed-meshheading:7558422-Apolipoproteins D,
pubmed-meshheading:7558422-Breast Neoplasms,
pubmed-meshheading:7558422-Carrier Proteins,
pubmed-meshheading:7558422-Cell Division,
pubmed-meshheading:7558422-Dexamethasone,
pubmed-meshheading:7558422-Dihydrotestosterone,
pubmed-meshheading:7558422-Drug Interactions,
pubmed-meshheading:7558422-Estradiol,
pubmed-meshheading:7558422-Estradiol Antagonists,
pubmed-meshheading:7558422-Glucocorticoids,
pubmed-meshheading:7558422-Glycoproteins,
pubmed-meshheading:7558422-Humans,
pubmed-meshheading:7558422-Interleukin-1,
pubmed-meshheading:7558422-Interleukin-6,
pubmed-meshheading:7558422-Kinetics,
pubmed-meshheading:7558422-Membrane Transport Proteins,
pubmed-meshheading:7558422-Neoplasm Proteins,
pubmed-meshheading:7558422-Stimulation, Chemical,
pubmed-meshheading:7558422-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Interleukin-6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin-1 alpha on apolipoprotein D and GCDFP-15 expression in human breast cancer cells.
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pubmed:affiliation |
Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Québec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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