Linked Life Data

7542056

Source:http://linkedlifedata.com/resource/pubmed/id/7542056

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1995-8-24
pubmed:abstractText
Eosinophils can synthesize various cytokines. We demonstrate that interleukin-8 (IL-8) mRNA and protein are constitutively expressed by freshly isolated resting human eosinophils. Most of the patients with bronchial asthma or atopic dermatitis show evidence for up-regulated IL-8 protein expression in eosinophils but not in neutrophils, suggesting that an eosinophil-specific cytokine may act in these patients. To investigate whether the intracellular IL-8 can be released, eosinophils were stimulated by different cytokines and platelet-activating factor (PAF). Priming with granulocyte/macrophage-colory-stimulating factor and a subsequent 25-min stimulation with RANTES or PAF resulted in release of IL-8 from highly purified human eosinophils in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1018-2438
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
124-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Human peripheral blood eosinophils express and release interleukin-8.
pubmed:affiliation
Swiss Institute of Allergy and Asthma Research (SIAF), Davos.
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't