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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-7-20
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pubmed:abstractText |
Sendide is a selective and extremely potent antagonist of neurokinin-1 (NK1) receptors in the mouse spinal cord. The antinociceptive activities of sendide, an antagonist of NK1 receptors, and its analogue, [D-Trp7]sendide have been examined after intrathecal (i.t.) administrations in the mouse paw formalin test. Intrathecal administration of sendide (in pmol) reduced both the early and late phases of the formalin-induced licking response. [D-Trp7]sendide also produced a significant antinociceptive response with less potent activity than sendide. Even highest doses (4000 pmol sendide and 8000 pmol [D-Trp7]sendide) examined, there was no motor paralysis of the hindlimbs. Intrathecal morphine inhibited both the early and late phases of the formalin-induced licking response in a dose-dependent manner. The results indicate that the antinociceptive effects of sendide and [D-Trp7]sendide may be mediated at NK1 receptors in the formalin-induced nociception.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3959
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-80
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7540280-Animals,
pubmed-meshheading:7540280-Behavior, Animal,
pubmed-meshheading:7540280-Formaldehyde,
pubmed-meshheading:7540280-Injections, Spinal,
pubmed-meshheading:7540280-Male,
pubmed-meshheading:7540280-Mice,
pubmed-meshheading:7540280-Mice, Inbred Strains,
pubmed-meshheading:7540280-Pain,
pubmed-meshheading:7540280-Pain Measurement,
pubmed-meshheading:7540280-Peptide Fragments,
pubmed-meshheading:7540280-Pyrrolidonecarboxylic Acid,
pubmed-meshheading:7540280-Receptors, Neurokinin-1,
pubmed-meshheading:7540280-Substance P
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pubmed:year |
1995
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pubmed:articleTitle |
The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test.
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pubmed:affiliation |
Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
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pubmed:publicationType |
Journal Article
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