| pubmed-article:7539892 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7539892 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:7539892 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7539892 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:7539892 | lifeskim:mentions | umls-concept:C0019691 | lld:lifeskim |
| pubmed-article:7539892 | lifeskim:mentions | umls-concept:C1325847 | lld:lifeskim |
| pubmed-article:7539892 | lifeskim:mentions | umls-concept:C0961954 | lld:lifeskim |
| pubmed-article:7539892 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:7539892 | pubmed:issue | 6531 | lld:pubmed |
| pubmed-article:7539892 | pubmed:dateCreated | 1995-7-10 | lld:pubmed |
| pubmed-article:7539892 | pubmed:abstractText | The depletion of CD4+ T cells in AIDS is correlated with high turnover of the human immunodeficiency virus HIV-1 and associated with apoptosis. The molecular mechanism of apoptosis in HIV infection, however, is largely unknown. T-cell apoptosis might be affected by viral proteins such as HIV-1 Tat and gp120 (refs 10, 11). T-cell-receptor (TCR)-induced apoptosis was recently shown to involve the CD95 (APO-1/Fas) receptor. We show here that HIV-1 Tat strongly sensitizes TCR- and CD4(gp120)-induced apoptosis by upregulation of CD95 ligand expression. Concentrations of Tat found to be effective in cultures of HIV-1-infected cells were also observed in sera from HIV-1-infected individuals. Taken together, our results indicate that HIV-1 Tat and gp120 accelerate CD95-mediated, activation-induced T-cell apoptosis, a mechanism that may contribute to CD4+ T-cell depletion in AIDS. | lld:pubmed |
| pubmed-article:7539892 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7539892 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7539892 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7539892 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7539892 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7539892 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7539892 | pubmed:author | pubmed-author:FrankRR | lld:pubmed |
| pubmed-article:7539892 | pubmed:author | pubmed-author:KrammerP HPH | lld:pubmed |
| pubmed-article:7539892 | pubmed:author | pubmed-author:DheinJJ | lld:pubmed |
| pubmed-article:7539892 | pubmed:author | pubmed-author:DebatinK MKM | lld:pubmed |
| pubmed-article:7539892 | pubmed:author | pubmed-author:WalczakHH | lld:pubmed |
| pubmed-article:7539892 | pubmed:author | pubmed-author:StrickerKK | lld:pubmed |
| pubmed-article:7539892 | pubmed:author | pubmed-author:WestendorpM... | lld:pubmed |
| pubmed-article:7539892 | pubmed:author | pubmed-author:OchsenbauerCC | lld:pubmed |
| pubmed-article:7539892 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7539892 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:7539892 | pubmed:volume | 375 | lld:pubmed |
| pubmed-article:7539892 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7539892 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7539892 | pubmed:pagination | 497-500 | lld:pubmed |
| pubmed-article:7539892 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7539892 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7539892 | pubmed:articleTitle | Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. | lld:pubmed |
| pubmed-article:7539892 | pubmed:affiliation | Tumorimmunology Program, German Cancer Research Centre, Heidelberg. | lld:pubmed |
| pubmed-article:7539892 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7539892 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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