|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6531
|
|
pubmed:dateCreated |
1995-7-10
|
|
pubmed:abstractText |
The depletion of CD4+ T cells in AIDS is correlated with high turnover of the human immunodeficiency virus HIV-1 and associated with apoptosis. The molecular mechanism of apoptosis in HIV infection, however, is largely unknown. T-cell apoptosis might be affected by viral proteins such as HIV-1 Tat and gp120 (refs 10, 11). T-cell-receptor (TCR)-induced apoptosis was recently shown to involve the CD95 (APO-1/Fas) receptor. We show here that HIV-1 Tat strongly sensitizes TCR- and CD4(gp120)-induced apoptosis by upregulation of CD95 ligand expression. Concentrations of Tat found to be effective in cultures of HIV-1-infected cells were also observed in sera from HIV-1-infected individuals. Taken together, our results indicate that HIV-1 Tat and gp120 accelerate CD95-mediated, activation-induced T-cell apoptosis, a mechanism that may contribute to CD4+ T-cell depletion in AIDS.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0028-0836
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
375
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
497-500
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7539892-Antigens, CD3,
pubmed-meshheading:7539892-Antigens, CD95,
pubmed-meshheading:7539892-Antigens, Surface,
pubmed-meshheading:7539892-Apoptosis,
pubmed-meshheading:7539892-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7539892-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7539892-Cell Line,
pubmed-meshheading:7539892-Cross-Linking Reagents,
pubmed-meshheading:7539892-Fas Ligand Protein,
pubmed-meshheading:7539892-Gene Products, tat,
pubmed-meshheading:7539892-HIV Envelope Protein gp120,
pubmed-meshheading:7539892-HIV Infections,
pubmed-meshheading:7539892-Humans,
pubmed-meshheading:7539892-Lymphocyte Activation,
pubmed-meshheading:7539892-Membrane Glycoproteins,
pubmed-meshheading:7539892-Receptors, Antigen, T-Cell,
pubmed-meshheading:7539892-T-Lymphocytes,
pubmed-meshheading:7539892-Tumor Cells, Cultured,
pubmed-meshheading:7539892-tat Gene Products, Human Immunodeficiency Virus
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.
|
|
pubmed:affiliation |
Tumorimmunology Program, German Cancer Research Centre, Heidelberg.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
