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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-7-7
|
| pubmed:abstractText |
Previously, we demonstrated that hepatocyte growth factor/scatter factor (HGF/SF) is expressed by human bone stromal cells and is a powerful mitogen to prostatic epithelial cells in culture. Based on these observations, we hypothesized that, if prostate cancer cells in the prostate or bone environment respond to HGF/SF as a mitogen, then they must express the HGF/SF receptor, which is coded by the c-met proto-oncogene. We used immunohistochemical techniques to: 1) assess the presence and localization of c-met protein in benign and malignant human prostate tissues and 2) correlate the presence of c-met protein with tumor stage, grade and androgen sensitivity. c-met protein immunostaining was consistently observed in the basal epithelial layer of normal prostate glands but was absent in luminal epithelial cells of the peripheral and transition zones. c-met protein immunostaining was detected in 10 of 11 foci (91%) of high grade prostatic intraepithelial neoplasia (PIN). Overall, c-met protein staining was noted in 36 of 43 (84%) primary prostate cancer samples versus 2 of 11 (18%) benign prostate hyperplasia samples (p < 0.0001) and in 4 of 4 (100%) lymph node metastases, 23 of 23 (100%) bone marrow metastases and 1 of 3 (33%) other metastatic sites. There was a clear relationship between c-met protein staining and higher grade adenocarcinomas (p < 0.001). c-met protein is frequently detected in PIN and higher grade prostate cancers; future studies should evaluate the biological significance of these findings.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-met,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-5347
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
154
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
293-8
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:7539865-Adenocarcinoma,
pubmed-meshheading:7539865-Adult,
pubmed-meshheading:7539865-Aged,
pubmed-meshheading:7539865-Aged, 80 and over,
pubmed-meshheading:7539865-Bone Marrow,
pubmed-meshheading:7539865-Bone Neoplasms,
pubmed-meshheading:7539865-Epithelium,
pubmed-meshheading:7539865-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:7539865-Hepatocyte Growth Factor,
pubmed-meshheading:7539865-Humans,
pubmed-meshheading:7539865-Lymphatic Metastasis,
pubmed-meshheading:7539865-Male,
pubmed-meshheading:7539865-Middle Aged,
pubmed-meshheading:7539865-Neoplasm Staging,
pubmed-meshheading:7539865-Prostate,
pubmed-meshheading:7539865-Prostatic Hyperplasia,
pubmed-meshheading:7539865-Prostatic Neoplasms,
pubmed-meshheading:7539865-Proto-Oncogene Proteins,
pubmed-meshheading:7539865-Proto-Oncogene Proteins c-met,
pubmed-meshheading:7539865-Receptor Protein-Tyrosine Kinases
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
c-met proto-oncogene expression in benign and malignant human prostate tissues.
|
| pubmed:affiliation |
Department of Urology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|