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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1995-7-13
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pubmed:abstractText |
The secretion of tumor necrosis factor (TNF)-alpha from macrophages is regulated by both priming and triggering signals. We found that macrophages from mice lacking gamma delta T cells [T cell receptor (TCR) delta-/- mice], which lack the gene encoding the delta chain, produced only small amounts of TNF-alpha in response to lipopolysaccharide (LPS) and showed a reduced level of expression of CD14. Pre-incubation of macrophages from TCR delta-/- mice with gamma delta T cells from their TCR delta +/- littermates restored their capacity to produce TNF-alpha in response to LPS. The priming activity of gamma delta T cells was in part inhibited by neutralizing anti-interferon (IFN)-gamma monoclonal antibodies. Collectively, these results suggest that gamma delta T cells play a role in priming macrophages to a steady state of activation via IFN-gamma secretion, which allows them to produce TNF-alpha when exposed to LPS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1465-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7539762-Animals,
pubmed-meshheading:7539762-Antibodies, Monoclonal,
pubmed-meshheading:7539762-Antigens, CD,
pubmed-meshheading:7539762-Antigens, CD14,
pubmed-meshheading:7539762-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:7539762-Chimera,
pubmed-meshheading:7539762-Interferon-gamma,
pubmed-meshheading:7539762-Lipopolysaccharides,
pubmed-meshheading:7539762-Lymphocyte Activation,
pubmed-meshheading:7539762-Macrophage Activation,
pubmed-meshheading:7539762-Macrophages, Peritoneal,
pubmed-meshheading:7539762-Male,
pubmed-meshheading:7539762-Mice,
pubmed-meshheading:7539762-Mice, Inbred BALB C,
pubmed-meshheading:7539762-Mice, Knockout,
pubmed-meshheading:7539762-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:7539762-Signal Transduction,
pubmed-meshheading:7539762-Specific Pathogen-Free Organisms,
pubmed-meshheading:7539762-T-Lymphocyte Subsets,
pubmed-meshheading:7539762-Tumor Necrosis Factor-alpha
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pubmed:year |
1995
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pubmed:articleTitle |
The role of gamma delta T cells in priming macrophages to produce tumor necrosis factor-alpha.
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pubmed:affiliation |
Laboratory of Host Defense & Germfree Life, Nagoya University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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