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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-3-23
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pubmed:databankReference |
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pubmed:abstractText |
We have characterized the 5' region of the CALLA/CD10 gene which has been shown to be identical to the membrane-associated enzyme neutral endopeptidase 24.11 (NEP). There is no CAAT or TATA box in the 5' flanking region, upstream of exon 1, but a GC rich region with several Sp1 binding sites. We have detected several putative initiation transcription sites by primer extension and by nuclease S1 analysis. Moreover by reverse transcriptase-polymerase chain reaction, we demonstrated the existence of a new exon: exon 1bis. This exon can be alternatively spliced as has already been described for exon 1 and exon 2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
207
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
933-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7532408-Base Sequence,
pubmed-meshheading:7532408-Deoxyribonuclease EcoRI,
pubmed-meshheading:7532408-Exons,
pubmed-meshheading:7532408-Humans,
pubmed-meshheading:7532408-Molecular Sequence Data,
pubmed-meshheading:7532408-Neprilysin,
pubmed-meshheading:7532408-Oligonucleotide Probes,
pubmed-meshheading:7532408-Polymerase Chain Reaction,
pubmed-meshheading:7532408-RNA, Messenger,
pubmed-meshheading:7532408-RNA-Directed DNA Polymerase,
pubmed-meshheading:7532408-Single-Strand Specific DNA and RNA Endonucleases,
pubmed-meshheading:7532408-TATA Box,
pubmed-meshheading:7532408-Transcription, Genetic
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pubmed:year |
1995
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pubmed:articleTitle |
Characterization of the 5' region of the CD10/neutral endopeptidase 24.11 gene.
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pubmed:affiliation |
INSERM U268, Hôpital Paul Brousse, Villejuif, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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