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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-3-13
|
| pubmed:abstractText |
The presence of proteoglycans in fibrous long-spacing collagen (FLSC) was assessed in various pathologic tissues using the highly selective proteoglycan stains cuprolinic blue and polyethyleneimine. Two types of FLSC could be distinguished: one that contained proteoglycans and one that did not. The conditions in which these types occurred suggested a completely different physiologic significance. Also, their morphologies were different: The FLSC containing proteoglycans constituted compact, often fusiform structures long known in diagnostic electron microscopy as Luse bodies. In accordance with the literature, this compact type of FLSC was found especially in schwannomas and other neurogenic tumors. Enzymatic digestion experiments indicated that the proteoglycan present was dermatan sulfate proteoglycan. The average periodicities measured ranged from 101 to 147 nm. The type of FLSC lacking proteoglycans, on the other hand, formed dispersed aggregates. This dispersed FLSC had periodicities ranging from 79 to 103 nm (ie, just below those of the compact type). It was found only under circumstances in which there was high collagen breakdown and/or turnover. That dispersed FLSC is a marker for collagen degradation was further supported by its presence inside fibroblasts engaged in collagen phagocytosis.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0191-3123
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
539-47
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| pubmed:dateRevised |
2009-6-26
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| pubmed:meshHeading | |
| pubmed:articleTitle |
Long-spacing collagen and proteoglycans in pathologic tissues.
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| pubmed:affiliation |
Department of Pathology, University of Amsterdam, The Netherlands.
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| pubmed:publicationType |
Journal Article
|