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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-3-14
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pubmed:abstractText |
Neutrophil function was examined in rats treated with recombinant human granulocyte colony-stimulating factor (G-CSF) using peripheral blood neutrophils (PBNs) and peritoneal exudate neutrophils (PENs) as sources of cells examined in vitro. Adherence to plastic plates containing fetal calf serum of nonstimulated or N-formylmethionyl-leucyl-phenylalanine (fMLP)- or tumor necrosis factor-alpha-stimulated PBNs obtained from G-CSF-injected rats was lower than that of control rats. In contrast, this adherence was higher in G-CSF-treated rats than in the control group when PENs were used. Neutrophil adherence of G-CSF-injected and noninjected groups was identical when phorbol myristate acetate was used to stimulate neutrophils. Superoxide production of PBNs stimulated with fMLP in vitro was lower in G-CSF-treated rats than in control rats but higher than in the controls when PENs were used. Furthermore, in vitro tumor cell growth inhibition by PBNs was lower in G-CSF-treated rats than in control rats, but when PENs were used inhibition was higher than in the controls.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0741-5400
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
250-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7531746-Amino Acid Sequence,
pubmed-meshheading:7531746-Animals,
pubmed-meshheading:7531746-Ascitic Fluid,
pubmed-meshheading:7531746-Buffers,
pubmed-meshheading:7531746-Cell Adhesion,
pubmed-meshheading:7531746-Cell Division,
pubmed-meshheading:7531746-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:7531746-Male,
pubmed-meshheading:7531746-Molecular Sequence Data,
pubmed-meshheading:7531746-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:7531746-Neutrophils,
pubmed-meshheading:7531746-Phosphates,
pubmed-meshheading:7531746-Rats,
pubmed-meshheading:7531746-Rats, Wistar,
pubmed-meshheading:7531746-Superoxides,
pubmed-meshheading:7531746-Tetradecanoylphorbol Acetate,
pubmed-meshheading:7531746-Tumor Cells, Cultured,
pubmed-meshheading:7531746-Tumor Necrosis Factor-alpha
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pubmed:year |
1995
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pubmed:articleTitle |
Modulation of rat neutrophil functions by administration of granulocyte colony-stimulating factor.
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pubmed:affiliation |
Department of Immunology and Parasitology, Yamagata University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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