|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005740,
umls-concept:C0008838,
umls-concept:C0010583,
umls-concept:C0010934,
umls-concept:C0029939,
umls-concept:C0040808,
umls-concept:C0042670,
umls-concept:C0205851,
umls-concept:C0443252,
umls-concept:C1274040,
umls-concept:C1708878
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|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1995-1-24
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|
pubmed:abstractText |
21 patients with malignant germ cell tumours of the ovary were treated with two chemotherapy regimens including vinblastine, actinomycin-D, bleomycin, cyclophosphamide and cisplatin. Chemotherapy was delivered as primary postoperative therapy in 15 patients and for recurrent disease in 6 patients. 3 of 4 patients with pure dysgerminomas and 10 of 17 patients with non-dysgerminomatous tumours are alive without evidence of disease. The overall progression-free survival is 62% (95% confidence interval 45-77) with a median follow-up of 7 years. Two toxic deaths were observed. Less toxicity and better efficacy favour etoposide- and cisplatin-based regimens as standard chemotherapy for germ cell tumours of the ovary.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0959-8049
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
30A
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1239-44
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|
pubmed:dateRevised |
2006-4-24
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|
pubmed:meshHeading |
pubmed-meshheading:7528029-Adolescent,
pubmed-meshheading:7528029-Adult,
pubmed-meshheading:7528029-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7528029-Bleomycin,
pubmed-meshheading:7528029-Cisplatin,
pubmed-meshheading:7528029-Cyclophosphamide,
pubmed-meshheading:7528029-Dactinomycin,
pubmed-meshheading:7528029-Female,
pubmed-meshheading:7528029-Germinoma,
pubmed-meshheading:7528029-Humans,
pubmed-meshheading:7528029-Methotrexate,
pubmed-meshheading:7528029-Neoplasm, Residual,
pubmed-meshheading:7528029-Neoplasm Recurrence, Local,
pubmed-meshheading:7528029-Ovarian Neoplasms,
pubmed-meshheading:7528029-Salvage Therapy,
pubmed-meshheading:7528029-Tumor Markers, Biological,
pubmed-meshheading:7528029-Vinblastine,
pubmed-meshheading:7528029-Vincristine
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|
pubmed:year |
1994
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|
pubmed:articleTitle |
Long-term results of two VAB-like regimens (vinblastine + actinomycin-D + bleomycin + cyclophosphamide + cisplatin) in malignant germ cell tumours of the ovary.
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|
pubmed:affiliation |
Department of Medicine, Institut Gustave Roussy, France.
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pubmed:publicationType |
Journal Article
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