Linked Life Data

752455

Source:http://linkedlifedata.com/resource/pubmed/id/752455

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1979-9-17
pubmed:abstractText
Two experiments were conducted. In the first, 9 adult male subjects applied a marketed hair dye containing 2% lead acetate according to prescribed directions daily for a period of 90 days. Scalp, axillary and pubic hair were monitored for lead content before and at the end of the test period. Scalp hair analyses were used to confirm application of the hair dye; axillary and pubic hair were analyzed as biologic indicators of systemic lead absorption, i.e., metabolic incorporation of lead in hair growing at sites different from the dyed site. The axillary and pubic hair lead levels ranged from less than 6 to 41 ppm at the start and rose to 27 to 466 ppm at the conclusion of the experiment. Using 80 ppm hair lead as a measure of significant systemic absorption, 7 of 9 subjects showed this effect according to uptake by axillary hair and 4 of 9 according to pubic hair uptake. In the second experiment, blood and hair lead levels and blood erythroporphyrin were measured in 11 children from a pica clinic. Blood lead and hair lead levels were significantly correlated, i.e., r = +0.84. A regression formula was constructed relating these two parameters and blood lead values were predicted for the data of experiment 1, using observed hair lead values. The technique has important limitations; nevertheless, within these limitations, 1 of 9 subjects might be expected to have sustained an elevated blood lead level, i.e., in excess of 50 microgram/100 ml. It therefore appears that in the use of lead acetate hair dyes, some lead is absorbed systemically from the scalp.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1421-5721
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
196-204
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Exploratory skin penetration findings relating to the use of lead acetate hair dyes. Hair as a test tissue for monitoring uptake of systemic lead.
pubmed:publicationType
Journal Article