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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1994-10-18
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pubmed:abstractText |
Immunoreactivity for intercellular adhesion molecule-1 (ICAM-1) and for vascular cell adhesion molecule-1 (VCAM-1), two adhesion molecules of the immunoglobulin (Ig) superfamily, was tested and measured on tissue sections from 16 undifferentiated nasopharyngeal carcinomas (U-NPC), 12 keratinizing squamous cell carcinomas (SCCs) of the head and neck region, and 54 malignant epithelial tumors of various origin. Neoplastic cells of all cases of U-NPC were diffusely and intensely stained for ICAM-1 and VCAM-1. Moreover, ICAM-1 messenger RNA (mRNA) and VCAM-1 mRNA were detected by Northern blot analysis of RNA extracts from two tumors. In the other epithelial tumors focal or diffuse staining for ICAM-1 was observed in 40 cases (66%), whereas reactivity for VCAM-1 was detected in a single case of metastatic undifferentiated carcinoma of unknown origin. The biopsy specimens of U-NPC showed variable infiltration by leukocytes, which were positive for the integrins lymphocyte function antigen-1 (LFA-1) and alpha-4/beta-1, the corresponding ligands for ICAM-1 and VCAM-1. The possibility that ICAM-1 and VCAM-1 on neoplastic cells may favor the intratumoral recruitment of leukocytes in a way similar to that occurring in crypt epithelium of the palatine tonsil is discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0046-8177
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
924-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7522209-Adolescent,
pubmed-meshheading:7522209-Adult,
pubmed-meshheading:7522209-Aged,
pubmed-meshheading:7522209-Carcinoma,
pubmed-meshheading:7522209-Carcinoma, Squamous Cell,
pubmed-meshheading:7522209-Cell Adhesion Molecules,
pubmed-meshheading:7522209-Child,
pubmed-meshheading:7522209-Female,
pubmed-meshheading:7522209-Humans,
pubmed-meshheading:7522209-Immunoenzyme Techniques,
pubmed-meshheading:7522209-Intercellular Adhesion Molecule-1,
pubmed-meshheading:7522209-Male,
pubmed-meshheading:7522209-Middle Aged,
pubmed-meshheading:7522209-Nasopharyngeal Neoplasms,
pubmed-meshheading:7522209-Vascular Cell Adhesion Molecule-1
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pubmed:year |
1994
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pubmed:articleTitle |
Expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in undifferentiated nasopharyngeal carcinoma (lymphoepithelioma) and in malignant epithelial tumors.
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pubmed:affiliation |
Department of Experimental Medicine, Università La Sapienza, Roma, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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