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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-9-29
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pubmed:abstractText |
Binding of circulating cells to endothelium is mediated by recognition between endothelial adhesion molecules and their counter-receptors. The beta 2 integrins are a group of adhesion molecules, mainly expressed on leukocytes, that mediate intercellular binding by recognizing their counterparts on endothelial cells, among others ICAM-1. In this study we have studied the regulation of this interaction in myelomonocytic cells treated with genistein, a tyrosine kinase inhibitor with several other biological functions. We show that genistein upregulates the surface expression of the beta 2-integrins in the monoblastic THP-1 and to a lesser extent in the promyelocytic HL-60 leukemia cell lines. This upregulation leads to an increase in the adherence of THP-1 cells to ICAM-1. Genistein also modulates the expression of ICAM-1 on endothelial cells by potentiating the upregulating effect of TNF and IFN-gamma. Genistein may thus enhance intercellular binding by affecting both the endothelium and the circulating cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Genistein,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
203
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
443-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7521164-Antigens, CD,
pubmed-meshheading:7521164-Antigens, CD18,
pubmed-meshheading:7521164-Antineoplastic Agents,
pubmed-meshheading:7521164-Cell Adhesion,
pubmed-meshheading:7521164-Cell Adhesion Molecules,
pubmed-meshheading:7521164-Cell Line,
pubmed-meshheading:7521164-Flow Cytometry,
pubmed-meshheading:7521164-Gene Expression,
pubmed-meshheading:7521164-Genistein,
pubmed-meshheading:7521164-Humans,
pubmed-meshheading:7521164-Integrins,
pubmed-meshheading:7521164-Intercellular Adhesion Molecule-1,
pubmed-meshheading:7521164-Interferon-gamma,
pubmed-meshheading:7521164-Isoflavones,
pubmed-meshheading:7521164-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:7521164-Tumor Cells, Cultured,
pubmed-meshheading:7521164-Tumor Necrosis Factor-alpha,
pubmed-meshheading:7521164-Up-Regulation
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pubmed:year |
1994
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pubmed:articleTitle |
Genistein enhances the ICAM-mediated adhesion by inducing the expression of ICAM-1 and its counter-receptors.
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pubmed:affiliation |
Department of Bacteriology and Immunology, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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