Linked Life Data

7521156

Source:http://linkedlifedata.com/resource/pubmed/id/7521156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3A
pubmed:dateCreated
1994-9-26
pubmed:abstractText
Human benign hyperplastic prostate (BHP) tissues were implanted subcutaneously in male Beige nude mice for up to 16 weeks. The implants maintained the normal histological appearance of BPH without signs of atrophy for up to 6 weeks. Their epithelium expressed proliferating cell nuclear antigen (PCNA), demonstrating that these cells actively underwent cell division. Thereafter the tissues gradually became atrophic, and some tissues maintained for 16 weeks completely lost recognizable prostatic epithelium. The glandular epithelium tended to undergo squamous cell metaplasia associated with atrophy. The epithelial linings of the implants consistently expressed prostate-specific antigen and prostate acid phosphatase as demonstrated by immunohistochemistry, except in areas of severe atrophy and squamous metaplasia. The nuclei of the implants hybridized with a human-specific DNA probe. Continuous feeding of the mice with dihydrotestosterone or hydrocortisone did not change significantly the morphology or the proliferation index of the epithelial cells within the glandular alveoli of implanted tissues or of normal mouse prostates.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
943-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Maintenance of human benign prostatic hyperplasia tissues in the nude mouse.
pubmed:affiliation
Department of Chemical Carcinogenesis, Michigan Cancer Foundation, Detroit 48201.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't