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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-8-30
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pubmed:abstractText |
Nitric oxide (NO) production increases during sepsis and endotoxemia. Inhibition of NO synthase has been suggested as a therapeutic modality in sepsis and endotoxemia, but in recent reports NO synthase inhibition increased mortality rate. The mechanism of this phenomenon is not known. Other studies have shown that high levels of tumor necrosis factor (TNF) and interleukin-6 (IL-6) contribute to death during sepsis and endotoxemia. We tested the effect of NO synthase inhibition on survival in endotoxemic rats and hypothesized that inhibition of NO synthase during endotoxemia increases circulating levels of TNF and IL-6.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
332-7; discussion 337-8
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:7519365-Amino Acid Oxidoreductases,
pubmed-meshheading:7519365-Animals,
pubmed-meshheading:7519365-Arginine,
pubmed-meshheading:7519365-Endotoxins,
pubmed-meshheading:7519365-Interleukin-6,
pubmed-meshheading:7519365-Male,
pubmed-meshheading:7519365-Nitrates,
pubmed-meshheading:7519365-Nitric Oxide Synthase,
pubmed-meshheading:7519365-Nitrites,
pubmed-meshheading:7519365-Nitroarginine,
pubmed-meshheading:7519365-Rats,
pubmed-meshheading:7519365-Rats, Sprague-Dawley,
pubmed-meshheading:7519365-Tumor Necrosis Factor-alpha
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pubmed:year |
1994
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pubmed:articleTitle |
Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6.
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pubmed:affiliation |
Department of Surgery, University of Cincinnati Medical Center, Ohio.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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