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| pubmed-article:7515924 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
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| pubmed-article:7515924 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:7515924 | lifeskim:mentions | umls-concept:C2348042 | lld:lifeskim |
| pubmed-article:7515924 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7515924 | lifeskim:mentions | umls-concept:C0141826 | lld:lifeskim |
| pubmed-article:7515924 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7515924 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7515924 | pubmed:dateCreated | 1994-7-13 | lld:pubmed |
| pubmed-article:7515924 | pubmed:abstractText | Human peritoneal macrophages were exposed to increasing doses of LPS or a synthetic lipid A analogue (SDZ MRL 953) and production of the cytokines IL-1 beta, IL-6, TNF-alpha, and G-CSF was assessed at the protein and mRNA level. Cells were also prestimulated with low doses of LPS and SDZ MRL 953 to study their adaptation to a secondary challenge with high doses of LPS. The ability of macrophages to produce high levels of TNF-alpha and IL-6 after stimulation with LPS could be relieved almost completely by preincubating cells with low doses of LPS. Decreases of TNF-alpha and IL-6 production resulted from inhibition of gene transcription and/or changes in mRNA stability, as transcript levels of these cytokines were down-modulated by the process of LPS adaptation. Surprisingly, however, adapted cells were able to synthesize even larger quantities of G-CSF and IL-1 beta when exposed to a secondary LPS challenge. mRNA levels of the adapted cells remained unaltered for IL-1 beta, but were slightly increased for G-CSF as assessed by Northern blot analysis. High doses of the synthetic lipid A analogue SDZ MRL 953 were also able to adapt macrophages to a secondary LPS challenge by down-regulating TNF-alpha and IL-6 production, whereas priming secretion of G-CSF and IL-1 beta as well. We describe here the discordant adaptation of human peritoneal macrophages to a secondary LPS stimulus in vitro. These findings appear to have ramifications for the in vivo endotoxin response during inflammation and also Gram-negative septicemia. | lld:pubmed |
| pubmed-article:7515924 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7515924 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515924 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7515924 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7515924 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7515924 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7515924 | pubmed:author | pubmed-author:HerrmannFF | lld:pubmed |
| pubmed-article:7515924 | pubmed:author | pubmed-author:GalanosCC | lld:pubmed |
| pubmed-article:7515924 | pubmed:author | pubmed-author:EngelhardtRR | lld:pubmed |
| pubmed-article:7515924 | pubmed:author | pubmed-author:FreudenbergM... | lld:pubmed |
| pubmed-article:7515924 | pubmed:author | pubmed-author:OttoFF | lld:pubmed |
| pubmed-article:7515924 | pubmed:author | pubmed-author:SchumannR RRR | lld:pubmed |
| pubmed-article:7515924 | pubmed:author | pubmed-author:KnopfH PHP | lld:pubmed |
| pubmed-article:7515924 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7515924 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7515924 | pubmed:volume | 153 | lld:pubmed |
| pubmed-article:7515924 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7515924 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7515924 | pubmed:pagination | 287-99 | lld:pubmed |
| pubmed-article:7515924 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7515924 | pubmed:meshHeading | pubmed-meshheading:7515924-... | lld:pubmed |
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| pubmed-article:7515924 | pubmed:meshHeading | pubmed-meshheading:7515924-... | lld:pubmed |
| pubmed-article:7515924 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7515924 | pubmed:articleTitle | Discordant adaptation of human peritoneal macrophages to stimulation by lipopolysaccharide and the synthetic lipid A analogue SDZ MRL 953. Down-regulation of TNF-alpha and IL-6 is paralleled by an up-regulation of IL-1 beta and granulocyte colony-stimulating factor expression. | lld:pubmed |
| pubmed-article:7515924 | pubmed:affiliation | Department of Internal Medicine I, Freiburg University Medical Center, Germany. | lld:pubmed |
| pubmed-article:7515924 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7515924 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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