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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-5-26
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pubmed:abstractText |
Eighty breast cancer specimens were examined for insulin-like growth factor binding protein (IGFBP) expression by ligand blotting. Five distinct IGFBP species were found: a doublet at 48 and 44 kDa was IGFBP-3, the 34-kDa band was IGFBP-2, and a band at 24 kDa was IGFBP-4. A 32-kDa band was compatible with the migration position reported for IGFBP-5. IGFBP-3 was inversely correlated with ER expression, while IGFBP-4 was positively correlated with both ER and PgR. IGFBP-4 was also inversely correlated with S-phase fraction. Thus, IGFBP expression correlates with other parameters of breast cancer biology and may play a role in regulating tumor growth.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7512885-Breast Neoplasms,
pubmed-meshheading:7512885-Carrier Proteins,
pubmed-meshheading:7512885-Cell Division,
pubmed-meshheading:7512885-Female,
pubmed-meshheading:7512885-Humans,
pubmed-meshheading:7512885-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:7512885-Receptors, Estrogen,
pubmed-meshheading:7512885-Receptors, Progesterone,
pubmed-meshheading:7512885-Somatomedins
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pubmed:year |
1994
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pubmed:articleTitle |
Detection of insulin-like growth factor binding proteins (IGFBPs) by ligand blotting in breast cancer tissues.
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pubmed:affiliation |
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7884.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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