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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-3-31
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pubmed:abstractText |
Fc gamma RI and Fc gamma RIII expression on polymorphonuclear leucocytes in cord blood from seven normal infants was investigated by flow cytometry. Fc gamma R expression on fresh polymorphonuclear leucocytes in whole blood samples and in blood samples incubated with or without interferon gamma (IFN-gamma) for 48 hours was also studied. The percentage of Fc gamma RIII positive polymorphonuclear leucocytes in cord blood (73.3%) was significantly lower than that in adult controls (95.9%). The mean fluorescence intensity of Fc gamma RIII was significantly increased on cord polymorphonuclear leucocytes by the incubation with IFN-gamma. Fresh cord polymorphonuclear leucocytes expressed only a small amount of Fc gamma RI as adult polymorphonuclear leucocytes. The percentage of Fc gamma RI positive polymorphonuclear leucocytes induced with IFN-gamma was significantly higher in cord blood (62.3%) than in adult controls (30.3%). It is possible that decreased expression of Fc gamma RIII is a factor in the susceptibility of newborns to infection. High expression of Fc gamma RI stimulated with IFN-gamma in neonates could have a compensatory role against decreased immunological function.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-1703798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-1709195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-1797118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-1902126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2137491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2167908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2476506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2525933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2538508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2824655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2919119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2955043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2966197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-2967436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-3005468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-3017990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-3100615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-3113516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-3317253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-3719097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-5804185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7509591-6240017
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD29,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1359-2998
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
F31-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7509591-Adult,
pubmed-meshheading:7509591-Antigens, CD,
pubmed-meshheading:7509591-Antigens, CD14,
pubmed-meshheading:7509591-Antigens, CD29,
pubmed-meshheading:7509591-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:7509591-Cell Separation,
pubmed-meshheading:7509591-Cells, Cultured,
pubmed-meshheading:7509591-Fetal Blood,
pubmed-meshheading:7509591-Flow Cytometry,
pubmed-meshheading:7509591-Humans,
pubmed-meshheading:7509591-Infant, Newborn,
pubmed-meshheading:7509591-Interferon-gamma,
pubmed-meshheading:7509591-Neutrophils,
pubmed-meshheading:7509591-Receptors, IgG,
pubmed-meshheading:7509591-Time Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Fc gamma RI and Fc gamma RIII on polymorphonuclear leucocytes in cord blood.
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pubmed:affiliation |
Laboratory and Institute, Tokyo Women's Medical College, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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