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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1996-1-2
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pubmed:abstractText |
Haematopoietic stem cells in umbilical cord blood are an attractive target for gene therapy of inborn errors of metabolism. Three neonates with severe combined immunodeficiency were treated by retroviral-mediated transduction of the CD34+ cells from their umbilical cord blood with a normal human adenosine deaminase complementary DNA followed by autologous transplantation. The continued presence and expression of the introduced gene in leukocytes from bone marrow and peripheral blood for 18 months demonstrates that umbilical cord blood cells may be genetically modified with retroviral vectors and engrafted in neonates for gene therapy.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-1089883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-1348434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-1970972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-1974554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-2081193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-2342538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-2752148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-2835723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-2852134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-3047679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-3807953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-4117384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-4319233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-6087158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-7538356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-7691243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-7901474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-7914094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-8025266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-8098230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-8098231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-8433874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489356-8433875
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1017-23
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
pubmed-meshheading:7489356-Adenosine Deaminase,
pubmed-meshheading:7489356-Antigens, CD34,
pubmed-meshheading:7489356-Base Sequence,
pubmed-meshheading:7489356-Blood Transfusion, Autologous,
pubmed-meshheading:7489356-Bone Marrow,
pubmed-meshheading:7489356-DNA Primers,
pubmed-meshheading:7489356-Female,
pubmed-meshheading:7489356-Fetal Blood,
pubmed-meshheading:7489356-Gene Therapy,
pubmed-meshheading:7489356-Genetic Vectors,
pubmed-meshheading:7489356-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:7489356-Hematopoietic Stem Cells,
pubmed-meshheading:7489356-Humans,
pubmed-meshheading:7489356-Infant, Newborn,
pubmed-meshheading:7489356-Leukocytes,
pubmed-meshheading:7489356-Lymphocyte Transfusion,
pubmed-meshheading:7489356-Male,
pubmed-meshheading:7489356-Molecular Sequence Data,
pubmed-meshheading:7489356-Retroviridae,
pubmed-meshheading:7489356-Severe Combined Immunodeficiency,
pubmed-meshheading:7489356-Transduction, Genetic
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pubmed:year |
1995
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pubmed:articleTitle |
Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency.
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pubmed:affiliation |
Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital, Los Angeles, University of Southern California School of Medicine 90027, USA.
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pubmed:publicationType |
Journal Article
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