Linked Life Data

7481108

Source:http://linkedlifedata.com/resource/pubmed/id/7481108

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-11-30
pubmed:abstractText
We examined the hypothesis that medullary respiratory-related and non-respiratory-related neuronal activities are similarly altered with the "aspiration reflex", induced by mechanical stimulation of the epipharyngeal mucosa, and gasping, induced by severe hypoxia. Extracellular neuronal activities were recorded in decerebrate, paralyzed and ventilated cats. Phrenic activity and neuronal activities were monitored in eupnea and gasping. Seventy-one unit activities were recorded in the lateral medulla including the nucleus tractus solitorii (NTS), lateral tegmental field (LTF) and the nucleus ambiguus (NA). The respiratory modulation of a neuronal activity was quantified by a eta 2 statistic (Orem, J. and Dick, T., 1983, J. Neurophysiol. 50: 1098-1107). The eta 2 values of the units ranged from 0.02 to 0.93. Inspiratory-related activities with relative high eta 2 values (n = 16) were recorded in the region closed to the NTS. Phase-spanning (n = 7) and expiratory-related activities (n = 10) were recorded in the ventral medullary region. Units with low eta 2 values (n = 29) and with no spontaneous activity (n = 9) in eupnea were recorded in the region of the LTF. In both "aspiration reflex" and gasping, inspiratory-related activities were augmented and expiratory-related activities were suppressed. Tonic units were activated and additional activities were recruited. The modulation of the neuronal activities to gasping induced by anoxia was identical to that induced by pharyngeal stimulation in either hyperoxia or severe hypoxia. We concluded that medullary gasping mechanism is recruited by pharyngeal stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0034-5687
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-202
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Medullary neuronal activities in gasping induced by pharyngeal stimulation and hypoxia.
pubmed:affiliation
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756-0001, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.