Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-9-26
pubmed:abstractText
The binding of the chemotactic peptide N-formylnorleucylleucylphenylalanine (FNLLP) to its receptor on rabbit polymorphonuclear leukocytes (PMNs) modulates the number of available peptide receptors. Incubation with FNLLP decreases subsequent binding capacity, a phenomenon that has been termed receptor down regulation. Down regulation of the chemotactic peptide receptor is concentration dependent in both the rate and extent of receptor loss. The dose response parallels that of FNLLP binding to the recptor. The time-course is rapid; even at concentrations of FNLLP as low as 3 x 10(-9) M, the new equilibrium concentration of receptors is reached within 15 min. Down regulation is temperature dependent, but does occur even at 4 degrees C. Concomitant with down regulation, some of the peptide becomes irreversibly cell associated. At 4 degrees C, there is a small accumulation of nondissociable peptide that rapidly reaches a plateau. At higher temperatures, accumulation of nondissociable peptide continues after the rceptor number has reached equilibrium, and the amount accumulated can exceed the initial number of receptors by as much as 300%. The dose response of peptide uptake at 37 degrees C reflects that of binding, suggesting that it is receptor mediated. This uptake may occur via a pinocytosis mechanism. Although PMNs have not been considered to be pinocytic, the addition of FNLLP causes a fourfold stimulation of the rate of pinocytosis as measured by the uptake of [3H]sucrose.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-1093163, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-1127383, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-1262785, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-169886, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-189939, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-191816, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-198405, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-209335, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-210185, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-214444, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-221835, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-226968, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-233264, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-25378, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-25886, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-264125, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-265563, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-302450, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-4108781, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-4175690, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-457760, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-4654870, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-472759, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-479314, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-558197, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-5642465, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-567224, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-5765461, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-641351, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-680137, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-762249, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-836328, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-874088, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-948752, http://linkedlifedata.com/resource/pubmed/commentcorrection/7391138-977646
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
703-11
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Chemotactic peptide receptor modulation in polymorphonuclear leukocytes.
pubmed:publicationType
Journal Article