fMet-Leu-Phe receptor

Source:http://linkedlifedata.com/resource/umls/id/C0118022

MSH: A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.,NCI: fMet-Leu-Phe Receptor (350 aa, 38 kD) is a cell motility protein that is encoded by the human FPR1 gene and has roles in chemotaxis and signaling pathways including those mediated by nitric oxide, cAMP and activation of MAP kinase.

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