Linked Life Data

7350037

Source:http://linkedlifedata.com/resource/pubmed/id/7350037

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-2-15
pubmed:abstractText
The concept that an absence of apoprotein B in plasma may result in increased cholesterol biosynthesis was investigated by sterol balance techniques in 2 male patients with abetalipoproteinemia, one an adult, the other a child. Total body synthesis of cholesterol in both the adult patient (19.3 +/- 3.8 mg/kg/day vs. 10.8 +/- 0.9 mg/kg/day in controls) and the child with abetalipoproteinemia (34.9 mg/kg/day vs. 14.5 +/- 3.8 mg/kg/day in control children) was significantly higher than in controls whereas bile acid synthesis was similar in both groups. Absorption of orally administered [1,2-3H]cholesterol was lower in the abetalipoproteinemic subjects than the controls and subsequent labeling of plasma cholesterol in the former patients was minimal (less than 3% of controls). The mechanisms for the increased sterol synthesis in abetalipoproteinemia may relate to the absence of chylomicrons and low density lipoproteins in plasma, but the magnitude of the increase can be largely explained on the basis of enhanced sterol losses that occur secondary to malabsorption of biliary cholesterol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Lipid metabolism in abetalipoproteinemia: a study of cholesterol absorption and sterol balance in two patients.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.