Linked Life Data

7338954

Source:http://linkedlifedata.com/resource/pubmed/id/7338954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1982-6-24
pubmed:abstractText
Induction of sister chromatid exchanges (SCEs) in cultures of Chinese hamster ovary cells by 10 anticholinesterase organophosphate insecticides was investigated. The insecticides were two phosphates (dichlorvos and dicrotophos), four sulfur-containing organophosphates (malathion, parathion, leptophos, and diazinon), and four oxygen analogs of the latter (malaoxon, paraoxon, leptophosoxon, and diazoxon). All of the compounds except diazinon induced statistically significant increases in SCE frequencies at concentrations between 0.03 and 1.0 mM. These results suggest that SCE induction is a common property of organophosphate insecticides. Compared to the sulfur-containing organophosphates, the oxygen analogs consistently produced higher SCE frequencies and had stronger antiproliferative activity. Compared to two known genotoxicants, doxorubicin and ethyl methanesulfonate, the ability of organophosphates to produce SCEs is much weaker.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-4108
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
939-46
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Induction of sister chromatid exchanges in Chinese hamster ovary cells by organophosphate insecticides and their oxygen analogs.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.