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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1982-3-13
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pubmed:abstractText |
A method has been developed for the determination of O,S,S-trimethylphosphorodithioate in the plasma, lung, liver, brain and thymus of rats using high-resolution gas chromatography. The organophosphorus compound was extracted from the biological sample with ethyl acetate and analysed on a carbowax 20M fused-silica capillary column with a nitrogen-phosphorus specific detector. O,S,S-Triethylphosphorodithioate was used as an internal standard added to the sample before extraction. The sensitivity of the method allowed the compound to be measured in 0.1-ml aliquots of plasma or in 20-mg wet weight of tissue down to a level of 5 ng/sample. The method has been applied to a pharmacokinetic study in the rat after an oral or intravenous dosage with 25 mg/kg of O,S,S-trimethylphosphorodithioate.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen,
http://linkedlifedata.com/resource/pubmed/chemical/O,S,S-trimethyl phosphorodithioate,
http://linkedlifedata.com/resource/pubmed/chemical/Organothiophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophosphoric Acid Esters
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9673
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
219
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-90
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7320133-Animals,
pubmed-meshheading:7320133-Chromatography, Gas,
pubmed-meshheading:7320133-Female,
pubmed-meshheading:7320133-Nitrogen,
pubmed-meshheading:7320133-Organothiophosphorus Compounds,
pubmed-meshheading:7320133-Phosphorus,
pubmed-meshheading:7320133-Rats,
pubmed-meshheading:7320133-Rats, Inbred Strains,
pubmed-meshheading:7320133-Thiophosphoric Acid Esters,
pubmed-meshheading:7320133-Tissue Distribution
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pubmed:year |
1981
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pubmed:articleTitle |
The determination of O,S,S-trimethylphosphorodithioate in the plasma and various tissues of rats using high-resolution gas chromatography with nitrogen-phosphorus detection.
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pubmed:publicationType |
Journal Article
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