Linked Life Data

7155635

Source:http://linkedlifedata.com/resource/pubmed/id/7155635

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-3-11
pubmed:abstractText
Renal function was investigated in rats 3 d or 4 wk after an injection of 2-bromoethylamine hydrobromide (BEA) 40-125 mg/kg body weight. Animals developed necrosis of renal papillary structures other than collecting ducts (subtotal renal papillary necrosis) (RPN) or necrosis of all structures in the distal papilla, including collecting ducts (total RPN). Glomerular filtration rate (GFR) was reduced in animals with total RPN (667 +/- SD 168 microliters/min/100 g body weight, n = 5) in comparison with controls (1065 +/- 103, n = 5; P less than 0.001) but was unimpaired in animals with subtotal RPN (1162 +/- 200, n = 4; P greater than 0.3). Maximum urinary osmolality (Umax) was significantly decreased in subtotal RPN (1241 +/- 388 mOsm/kg, n = 4) and in total RPN (626 +/- 293, n = 5) in comparison with controls (2216 +/- 293, n = 5). Free water reabsorption (TcH2O) was impaired in animals with total RPN but was not significantly reduced in the presence of subtotal RPN. Total RPN did not affect free water formation (CH2O). It is concluded that impaired TcH2O occurs in RPN because of the damage to the collecting duct, and not because of necrosis of the thin limbs juxtamedullary nephrons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-3025
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
383-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Localization of medullary functional abnormalities in experimental papillary necrosis.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't