Linked Life Data

7064710

Source:http://linkedlifedata.com/resource/pubmed/id/7064710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1982-5-21
pubmed:abstractText
There is evidence that GABA acts as the excitatory neurotransmitter at synapses between vestibular hair cells and the afferent fibres in the mammalian labyrinth. The question arose as to whether certain vestibular dysfunctions such as labyrinthine vertigo could be treated in patients by influencing the peripheral GABA system by means of the GABA antagonist picrotoxin, a well known analeptic drug. With the application of slow infusion rates of only milligrams of picrotoxin a distinct suppression of peripheral spontaneous nystagmus, caloric excitability of labyrinths, and labyrinthine vertigo, without general CNS-induced arousal effect, was observed. A latent central spontaneous nystagmus can become manifest, whereas a manifest central spontaneous nystagmus remains unchanged. A future application of picrotoxin as a diagnostic and therapeutic tool in cases involving vestibular disorders is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6489
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Suppressive action of picrotoxin, a GABA antagonist, on labyrinthine spontaneous nystagmus and vertigo in man.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't