Linked Life Data

7042998

Source:http://linkedlifedata.com/resource/pubmed/id/7042998

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-7-19
pubmed:abstractText
Furosemide is a very commonly used loop diuretic in current clinical practice. Ototoxicity is a significant side effect which may be transient or permanent. Investigations into the mechanisms of furosemide ototoxicity have used pharmacologic, neurophysiologic, and morphologic methods, but the exact mode of production of ototoxicity is unknown. Aminoglycoside antibiotics potentiate furosemide ototoxicity, but noise trauma apparently does not. Methods of avoiding ototoxicity are suggested including slow continuous infusion rather than bolus injection, use of divided oral dose regimens, and the measurement of blood levels to avoid exceeding 50 mcg/ml of furosemide. If a diuretic response cannot be obtained using the above measures, the substitution of another diuretic such as bumetanide is suggested to maintain the therapeutic response and minimize the ototoxicity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0381-6605
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Pathophysiology of furosemide ototoxicity.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't