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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1980-7-22
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pubmed:abstractText |
The distribution of nerve growth factor (NGF) in rat pheochromocytoma cells (clone PC12) has been studied with two different techniques: immunofluorescence and autoradiography. It was found that NGF is progressively internalized in the cytoplasmic compartment and eventually accumulates in the form of discrete dots around the nucleus. A fraction of the internalized NGF appears within the nucleoplasm, often contiguous with the nucleolus. It is suggested that cytoplasmic and perinuclear NGF may be be in contact with a pool of tubulin or actin-like proteins in their soluble or organized form and play a key role in the process of arrest of division and neurite growth.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-1065897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-14330683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-149985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-16578496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-172344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-238651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-271981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-286309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-329148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-337307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-391571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-4525323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-455435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-4875350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-4982360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-5802485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-789100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990413-819632
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1656-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6990413-Actins,
pubmed-meshheading:6990413-Autoradiography,
pubmed-meshheading:6990413-Cell Nucleus,
pubmed-meshheading:6990413-Cells, Cultured,
pubmed-meshheading:6990413-Cytoplasm,
pubmed-meshheading:6990413-Fluorescent Antibody Technique,
pubmed-meshheading:6990413-Neoplasms, Experimental,
pubmed-meshheading:6990413-Nerve Growth Factors,
pubmed-meshheading:6990413-Pheochromocytoma,
pubmed-meshheading:6990413-Tubulin
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pubmed:year |
1980
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pubmed:articleTitle |
Intracellular distribution of nerve growth factor in rat pheochromocytoma PC12 cells: evidence for a perinuclear and intranuclear location.
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pubmed:publicationType |
Journal Article
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