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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
1983-3-11
|
| pubmed:abstractText |
The roles of three homeotic genes, Ubx+, Scr+, and Antp+, in the Drosophila thorax have been studied by determining the cellular phenotypes of mutations resulting in loss of gene function. The principal results are: (i) The Scr+ and Ubx+ genes are required in the prothorax and metathorax, respectively; in the absence of these genes, both segments develop like the mesothorax. (ii) The Antp+ gene is required in all three thoracic segments: in its absence, parts of the mesothorax are transformed into corresponding parts of the antenna, and similar transformations to antenna are found in the prothorax and metathorax if the Scr+ and Ubx+ genes also are absent. (iii) Loss of the Ubx+ gene early in embryogenesis, but not later, leads to the inappropriate activity of the Scr+ gene in the meso- and metathorax. Results i and ii argue strongly that segmental determination is specified in a combinatorial fashion in the head and thorax by the selective activities of the Scr+, Ubx+, Antp+, and putative head-determining genes. Result iii suggests that a product of the Ubx+ gene also plays an early, regulatory role in ensuring the correct spatial expression of the Scr+ gene during subsequent development.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-103000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-1039909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-1116643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-17248988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-17249041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-17249042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-4518369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-6780396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-6780397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-7108423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-7219563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-7254358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-7266657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6961417-805750
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0027-8424
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
79
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
7380-4
|
| pubmed:dateRevised |
2010-9-13
|
| pubmed:meshHeading | |
| pubmed:year |
1982
|
| pubmed:articleTitle |
Genes controlling segmental specification in the Drosophila thorax.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|