Linked Life Data

6896695

Source:http://linkedlifedata.com/resource/pubmed/id/6896695

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1982-10-21
pubmed:abstractText
By means of glass-capillary-gas chromatography all possible benz[a]anthracene metabolites formed by rat liver microsomes (phenols, dihydrodiols, dihydrodiol enols and tetrahydrotetrols) can be separated. Mass spectra of their trimethylsilyl ethers show intense molecule ions and, in most cases, characteristic fragments. K-Region diols and their secondary oxidation products can be recognized by the ratio (m/e 147) (m/e 191) greater than 1, whereas the ratio is inverse in all other dihydrodiol trimethylsilyl ethers investigated. With the exception of 1,2-dihydrobenz[a]anthracene-1,2,3-triol all vicinal dihydrodiol enols investigated exhibit an intense elimination of the fragment CH = CH-OSiMe3 according to m/e 379. The conformation of vicinal tetrahydrobenz[a]anthracenetetrols possibly can be distinguished by the intensity of m/e 380 (M - 240) since only in those possessing two or more subsequent Me3SiO groups in the same conformation intense elimination of Me3Si-O-CH = CH-O-SiMe3 is observed. Retention times and mass spectrometric data of a series of synthetic benz[a]anthracene derivatives are presented as a base for the identification of benz[a]anthracene metabolites in biological systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0018-4888
pubmed:author
pubmed:issnType
Print
pubmed:volume
362
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1021-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Glass-capillary-gas chromatography/mass spectrometry data of mono- and polyhydroxylated benz[a]anthracene. Comparison with benz[a]anthracene metabolites from rat liver microsomes.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't