Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-10-27
pubmed:abstractText
Dihydrofolate reductases from the folate-requiring strains Streptococcus faecalis ATCC 8043, Lactobacillus casei ATCC 7496, and Pediococcus cerevisiae ATCC 8081, as well as from Lactobacillus arabinosus, which is not dependent on exogenous folate, were isolated, and their properties were compared to reductases of Escherichia coli B, Staphylococcus aureus, and rat liver reductase. An inhibition profile with six different inhibitors revealed significant differences among all enzymes. All lactobacilli reductases are less sensitive to trimethoprim than the enzymes of E. coli and S. aureus, the reductase of P. cerevisiae requiring a concentration at least 1,000 times higher for 50% inhibition. Inhibition of growth of S. faecalis by pyrimethamine and 2,4-diamino-6,7-diisopropyl-pteridine was seen to be much stronger than was predicted from the enzymatic data.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-1084551, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-1097435, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-13403124, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-13786515, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-137981, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-13845830, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-14961, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-15830489, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-237891, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-320005, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-405008, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-408191, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-4207496, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-4208273, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-4378654, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-4540970, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-4863042, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-4943573, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-5025031, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-5242160, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-5473888, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-6054, http://linkedlifedata.com/resource/pubmed/commentcorrection/686702-850245
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Dihydrofolate reductases in some folate-requiring bacteria with low trimethoprim susceptibility.
pubmed:publicationType
Journal Article