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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1982-10-12
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pubmed:abstractText |
Following a 24 h control period in the ward 80 mg furosemide was injected intravenously to ten young healthy, male volunteers. The serum clearance of furosemide (Cls) was between 140 and 201 ml min-1 and on the average the renal clearance was 60% of Cls. During the initial 30 min period a maximum additional excretion rate of sodium of 3.3 mmol min-1 was reached at an excretion rate of 0.8 mg furosemide min-1. A marked initial drop in creatinine clearance (Clcr) was noted and Clcr(24 h) showed an average decrease of 12% after the drug administration. The serum concentration of potassium was decreased at 1 and 2 h after the injection and of sodium from 2 h and on. The concentration of albumin in serum increased by 3% (P less than 0.05) already after 5 min. After 2 h a maximum increase of 14% was reached. After 8 min diastolic blood pressure was increased by 13% (P less than 0.05), whereas systolic blood pressure reached a significant decrease gradually (7% after 3 h).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Furosemide,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2972
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-55
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6809473-Adult,
pubmed-meshheading:6809473-Albuminuria,
pubmed-meshheading:6809473-Blood Pressure,
pubmed-meshheading:6809473-Creatinine,
pubmed-meshheading:6809473-Furosemide,
pubmed-meshheading:6809473-Humans,
pubmed-meshheading:6809473-Kidney Function Tests,
pubmed-meshheading:6809473-Kinetics,
pubmed-meshheading:6809473-Male,
pubmed-meshheading:6809473-Potassium,
pubmed-meshheading:6809473-Protein Binding,
pubmed-meshheading:6809473-Serum Albumin,
pubmed-meshheading:6809473-Sodium
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pubmed:year |
1982
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pubmed:articleTitle |
The individual variation in pharmacokinetics and pharmacodynamics of furosemide in young normal male subjects.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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