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rdf:type |
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lifeskim:mentions |
umls-concept:C0006376,
umls-concept:C0013832,
umls-concept:C0016860,
umls-concept:C0071132,
umls-concept:C0205307,
umls-concept:C0221102,
umls-concept:C0681850,
umls-concept:C0935936,
umls-concept:C1280500,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
2
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pubmed:dateCreated |
1978-10-27
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pubmed:abstractText |
1. The pharmacological actions of a new short acting loop diuretic were investigated in nine healthy male subjects and compared with those of frusemide and bumetanide. Subjects received 6 mg piretanide/day, 40 mg frusemide/day or 1 mg bumetanide/day for a period of 1 week. 2. Comparison of effects following the first dose administered showed that 6 mg piretanide is of similar potency to 40 mg frusemide in terms of diuresis, natriuresis and kaliuresis but is less potent than 1 mg bumetanide. 3. All three diuretics caused a decrease in urate excretion and a rise in serum uric acid. 4. Piretanide was well tolerated. Further investigation is required to ascertain what clinical advantage it offers over frusemide and bumetanide.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-1277709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-13874135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-4372013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-4556970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-4574445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-4590799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-4897753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-4929385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-5420637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-5785902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-5908364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-5934250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/678389-861127
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0306-5251
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:678389-Adult,
pubmed-meshheading:678389-Bumetanide,
pubmed-meshheading:678389-Diuretics,
pubmed-meshheading:678389-Electrolytes,
pubmed-meshheading:678389-Furosemide,
pubmed-meshheading:678389-Humans,
pubmed-meshheading:678389-Male,
pubmed-meshheading:678389-Potassium,
pubmed-meshheading:678389-Sodium,
pubmed-meshheading:678389-Time Factors,
pubmed-meshheading:678389-Uric Acid
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pubmed:year |
1978
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pubmed:articleTitle |
Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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