Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-7-22
pubmed:abstractText
Repair- and recombination-defective mutations at two loci (mei-9 and mei-41) of Drosophila melanogaster have been examined for their effects on the induction of chromosome aberrations by x-rays and the formation of sister chromatid exchanges (SCEs). Irradiation of larval neuroblast cells during the S phase with x-rays showed that mutants at both of these loci are about 10 times more sensitive than wild type to the induction of chromosome aberrations. The pattern of induced aberrations was characteristic for each mutant locus: in cells bearing mei-9 mutations most breaks were chromatid deletions, whereas in the presence of mei-41 mutations similar frequencies of chromatid and isochromatid deletions were observed. Furthermore, chromatid interchanges could not be induced in cells carrying mei-9 alleles; therefore these mutations define a step necessary for chromatid rejoining. mei-41 alleles also define a function involved in the formation of chromatid interchanges; total exchanges were less frequent than expected from nonmutant controls; and the proportion of exchanges arising by symmetrical rejoining was markedly reduced. These data indicate that chromatid and isochromatid deletions have different molecular steps in their formation, and that different molecular mechanisms are also involved in the symmetrical and unsymmetrical rejoining in chromatid interchanges. Neuroblast cells of larvae bearing mei-9 and mei-41 alleles were also treated for 13 hr with 5-bromodeoxyuridine at 9 mug/ml in order to differentiate sister chromatids for the scoring of SCEs. Whereas mei-41 had a normal level of SCEs, mei-9 exhibited a frequency of SCEs that was about 70% that of the control. Because both mei-9 and mei-41 mutations result in defective meiotic recombination, these data suggest that they define steps shared by symmetrical interchange formation and meiotic recombination that do not participate in the formation of most SCEs.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-1060089, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-108678, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-109350, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-1108765, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-118375, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-119665, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-1256589, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-13854500, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-17248870, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-187527, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-189178, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-324942, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-4140506, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-414131, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-4208856, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-4214530, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-4356741, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-4448109, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-4464237, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-4625747, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-50557, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-52431, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-54281, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-74232, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-797314, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-814449, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-825857, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-826451, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-826452, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-837800, http://linkedlifedata.com/resource/pubmed/commentcorrection/6769115-895755
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1575-9
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Relationships among chromatid interchanges, sister chromatid exchanges, and meiotic recombination in Drosophila melanogaster.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.