Linked Life Data

6685639

Source:http://linkedlifedata.com/resource/pubmed/id/6685639

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1984-1-26
pubmed:abstractText
Venous blood was taken from patients with cancer, prior to and up to 42 days after the administration of cytotoxic chemotherapy. Lymphocytes were stimulated to divide in vitro, and examined for sister chromatid exchanges (SCEs). Cyclophosphamide rapidly increased the frequency of SCE, which returned to approximately double the control value 24 hr after administration. The remaining SCEs disappeared more slowly. There was a positive correlation between the dose of drug and the frequency of SCE measured immediately and 4 hr, 20 hr and 21 days after treatment. As patients received successive courses of treatment the number of SCEs generally increased from about 0.14 to 0.25 per chromosome. After this, further chemotherapy was often less effective in inducing them. The presence of SCEs in peripheral blood lymphocytes may be a useful indicator for the occurrence and persistence of alkylating metabolites, residual damage in the DNA and individual responses of patients to a standard regimen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0277-5379
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1509-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The quantitation of sister chromatid exchanges in lymphocytes of cancer patients at intervals after cytotoxic chemotherapy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't