rdf:type |
|
lifeskim:mentions |
umls-concept:C0008838,
umls-concept:C0032207,
umls-concept:C0037211,
umls-concept:C0038925,
umls-concept:C0046537,
umls-concept:C0057856,
umls-concept:C0085080,
umls-concept:C0205263,
umls-concept:C0206135,
umls-concept:C0600596,
umls-concept:C1412362,
umls-concept:C1420492,
umls-concept:C1533691
|
pubmed:issue |
6
|
pubmed:dateCreated |
1984-2-21
|
pubmed:abstractText |
Sister chromatid exchange (SCE) induction by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis-platinum metronidazole2 Cl2 (FLAP] was studied in CHO cells in vitro. Both drugs induced SCE in a dose dependent manner. CHIP was a much more potent inducer of SCE than FLAP and produced almost 4 times as many SCE as FLAP at equimolar concentrations and twice as many at equitoxic dosage. Induction of SCE by a component of the FLAP molecule--metronidazole--was also examined. It did not cause any increase of SCE frequency over the control level when applied at 10 times the highest concentration of FLAP which was used.
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-1207711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-1240592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-392602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-4138930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-440327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-528286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-52847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-6156589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-6182579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-6849795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-6890846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-6984033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-6987501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-714079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-7378711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-74232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6652019-954143
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0007-0920
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
48
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
803-7
|
pubmed:dateRevised |
2011-9-13
|
pubmed:meshHeading |
pubmed-meshheading:6652019-Animals,
pubmed-meshheading:6652019-Antineoplastic Agents,
pubmed-meshheading:6652019-Cell Line,
pubmed-meshheading:6652019-Cricetinae,
pubmed-meshheading:6652019-Cricetulus,
pubmed-meshheading:6652019-Crossing Over, Genetic,
pubmed-meshheading:6652019-Dose-Response Relationship, Drug,
pubmed-meshheading:6652019-Metronidazole,
pubmed-meshheading:6652019-Mitosis,
pubmed-meshheading:6652019-Organoplatinum Compounds,
pubmed-meshheading:6652019-Radiation-Sensitizing Agents,
pubmed-meshheading:6652019-Sister Chromatid Exchange
|
pubmed:year |
1983
|
pubmed:articleTitle |
Sister chromatid exchanges induced by two radiosensitizing platinum compounds (cis-dichloro-bis isopropylamine trans dihydroxy platinum IV (CHIP) and cis platinum metronidazole2Cl2(FLAP)) in CHO cells in vitro.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|