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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1983-10-8
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pubmed:abstractText |
Several isolates of human T-cell leukemia/lymphoma virus (HTLV) were transmitted to normal human T cells obtained from the umbilical cord blood of newborns. T cells from seven specimens were immortalized by infection with different HTLV isolates and their properties were compared with those of activated uninfected normal T cells grown in the presence of T-cell growth factor (TCGF) and with those of HTLV-positive neoplastic T-cell lines derived from patients with T-cell malignancies. The HTLV-infected cells generally belonged to a class of mature T cells (OKT4+ and Leu 3A+) and differed from the normal uninfected cells in that they could be propagated in culture indefinitely; possessed altered morphology, including convoluted nuclei and some bi- and multinucleated giant cells; formed large clumps in culture; demonstrated a diminished requirement for TCGF; had an increased density of TCGF receptors; often became completely independent of exogenous TCGF; and expressed HLA-DR determinants. These properties of the HTLV-infected cord blood T cells contrasted to those of uncultured cord blood T cells and of cord blood cells stimulated with mitogen and grown with TCGF but resembled the characteristics of T-cell lines established previously from patients with HTLV-associated T-cell malignancies. This in vitro system offers a unique opportunity to study the basic mechanism involved in abnormal growth and neoplastic transformation of a specific class of human T cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-181845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-4327008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6121963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6256763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6261256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6262827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6264163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6274993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6275274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6290401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6296859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6600519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6601276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6760397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6815536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6951204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6969402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6972470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6975346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6979048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6980467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6980936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6981847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6982418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-6982476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-791375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6604273-87422
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5402-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6604273-Cell Division,
pubmed-meshheading:6604273-Cell Line,
pubmed-meshheading:6604273-Cell Transformation, Neoplastic,
pubmed-meshheading:6604273-Cells, Cultured,
pubmed-meshheading:6604273-Female,
pubmed-meshheading:6604273-Fetal Blood,
pubmed-meshheading:6604273-Humans,
pubmed-meshheading:6604273-Interleukin-2,
pubmed-meshheading:6604273-Kinetics,
pubmed-meshheading:6604273-Leukemia,
pubmed-meshheading:6604273-Pregnancy,
pubmed-meshheading:6604273-Retroviridae,
pubmed-meshheading:6604273-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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