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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0027819,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205282,
umls-concept:C0449258,
umls-concept:C0812287,
umls-concept:C1521871,
umls-concept:C1880177,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
15
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pubmed:dateCreated |
1984-9-19
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pubmed:abstractText |
Previous studies had revealed that DNA with partial similarity to the myc oncogene (N-myc) is frequently amplified in human neuroblastoma cell lines and neuroblastoma tumors. We show here for one patient that N-myc amplification is confined to the neuroblastoma tumor and is not present in normal tissue. N-myc mRNA approximately equal to 4.0 kilobases in size is detectable in neuroblastoma cell lines and tumors and in a retinoblastoma cell line. By contrast, appreciable amounts of this RNA were not present in a number of cell lines derived from other human tumors and in fibroblasts from a normal individual and from a neuroblastoma patient. Low levels of N-myc RNA were found in human and murine neuroblastoma cell lines lacking amplification of this gene, up to 80-fold greater levels in all cell lines carrying amplified N-myc. In situ hybridization to sections of neuroblastoma tumors revealed high expression of N-myc predominantly in undifferentiated neuroblasts. We hypothesize that amplification and consequent elevated expression of N-myc may be related to malignant progression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-14304929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-216014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-5031252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-5728342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6197179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6285209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6300869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6303940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6304530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6308652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6351725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6356357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6402307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6589609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6616438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6646201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6700732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6719137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6762516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6888561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-6955596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-715457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-71759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6589638-942798
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4940-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1984
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pubmed:articleTitle |
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
