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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1984-12-5
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pubmed:abstractText |
The effect of a combination of metolazone (0.2 to 0.4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone. Urinary volume increased from 24 +/- 14 mL/kg/d for patients receiving furosemide to 51 mL/kg/d with combined diuretic therapy (P less than .01), and sodium excretion increased from 34 +/- 5 mEq/d to 155 +/- 176 mEq/d (P less than .01). Two children with severe hypoalbuminemia (serum albumin level less than 1.5 g/dL) and normal renal function, and five children with chronic renal insufficiency (71%) did not respond to combined diuretic therapy. The combination of furosemide and metolazone offers a useful and effective oral therapy in most children with edema resistant to furosemide. Children with chronic renal insufficiency and furosemide-resistant edema did not respond to combination diuretic therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0031-4005
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
872-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6493882-Adolescent,
pubmed-meshheading:6493882-Child,
pubmed-meshheading:6493882-Child, Preschool,
pubmed-meshheading:6493882-Diuresis,
pubmed-meshheading:6493882-Diuretics,
pubmed-meshheading:6493882-Drug Evaluation,
pubmed-meshheading:6493882-Drug Resistance,
pubmed-meshheading:6493882-Drug Synergism,
pubmed-meshheading:6493882-Drug Therapy, Combination,
pubmed-meshheading:6493882-Edema,
pubmed-meshheading:6493882-Furosemide,
pubmed-meshheading:6493882-Humans,
pubmed-meshheading:6493882-Infant,
pubmed-meshheading:6493882-Kidney Failure, Chronic,
pubmed-meshheading:6493882-Metolazone,
pubmed-meshheading:6493882-Natriuresis,
pubmed-meshheading:6493882-Potassium,
pubmed-meshheading:6493882-Serum Albumin,
pubmed-meshheading:6493882-Sodium
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pubmed:year |
1984
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pubmed:articleTitle |
Efficacy of metolazone and furosemide in children with furosemide-resistant edema.
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pubmed:publicationType |
Journal Article,
Comparative Study
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