Linked Life Data

6488934

Source:http://linkedlifedata.com/resource/pubmed/id/6488934

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-12-12
pubmed:abstractText
We used a new micromethod, an application of a previously published high-performance liquid chromatography assay, to investigate trimethoprim (TMP) pharmacokinetics in children. The subjects were 5 girls who were treated for urinary tract infection with a TMP suspension, 6 mg/kg/day, twice daily for 10 days. Elimination studies were done after the last dose. The girls were 1.08-9.71 years old. 3 healthy adult males, aged 26.35-37.31 served as controls. The half-life (t 1/2) of TMP in the children was 3.0-5.5 versus 9.3-13.6 h in the adults. The volume of distribution (Vd) was 0.7-1.1 1/kg in the children and 0.5-0.9 1/kg in the adults. Plasma clearance (Clp) was 2.1-2.8 ml/min/kg for the children. The adults had a smaller Clp of 0.4-1.2 ml/min/kg. From this and previous studies we conclude that the t 1/2 of TMP is much shorter in children than in adults.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0009-3157
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-7
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Difference in trimethoprim pharmacokinetics between children and adults.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't