Linked Life Data

6465349

Source:http://linkedlifedata.com/resource/pubmed/id/6465349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1984-9-17
pubmed:abstractText
The preoptic area contains thermosensitive, osmosensitive, and glucosensitive neurons, which have been implicated in thermal, osmotic, and metabolite regulations, respectively. In this study, rat preoptic tissue slices are used to examine the specificity of these neurons by determining their individual firing rate responses to thermal, osmotic, and glucose stimuli. Of the neurons classified according to thermosensitivity, 35% were warm sensitive, 10% were cold sensitive, and 55% were temperature insensitive. Of these, 107 neurons were also tested for their responses to tissue slice perfusions of low-glucose and/or hyperosmotic media. These experimental perfusions affected one-third of the temperature-insensitive neurons and nearly half of the thermosensitive neurons and generally excited warm-sensitive neurons and inhibited cold-sensitive neurons. A lack of specificity was also observed between the groups of osmosensitive and glucosensitive neurons, since most of the responsive neurons were affected by both hyperosmotic and low-glucose media. Although these findings do not suggest a strong functional specificity for preoptic neurons, they do support previous studies that emphasize interactions between regulatory systems.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
247
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R335-45
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effects of osmotic pressure, glucose, and temperature on neurons in preoptic tissue slices.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't