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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1984-11-9
|
| pubmed:abstractText |
The comparative antiepileptic effects of the thyrotropin-releasing hormone and its new derivative, gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide citrate (DN-1417), were examined in feline amygdaloid kindling preparations. When tested in kindled animals, both agents showed a transient and non-dose-dependent anticonvulsant effect, in addition to raising the generalized convulsive seizure-triggering threshold for a prolonged period of time. Furthermore, DN-1417 exerted a significant effect on postictal events: shortening the electrographic silence, leaving the duration of slow activity intact, while prolonging the period of seizure refractoriness. When tested in kindling animals, DN-1417 showed a significant but non-dose-dependent prophylactic effect on both primary and secondary amygdaloid sites.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0013-9580
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
537-44
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1984
|
| pubmed:articleTitle |
Antiepileptic effects of thyrotropin-releasing hormone and its new derivative, DN-1417, examined in feline amygdaloid kindling preparation.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|