Linked Life Data

6383402

Source:http://linkedlifedata.com/resource/pubmed/id/6383402

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-10-17
pubmed:abstractText
The net uptake of 45Ca into mitochondria from pancreatic islets is stimulated by substrates that transfer reducing equivalents to various sites of the respiratory chain, such as succinate or glycerol 3-phosphate (site II), malate plus pyruvate (site I) or ascorbate plus TMPD (site III). Diazoxide, a known inhibitor of insulin release in vivo and in vitro, strongly inhibited net 45Ca uptake supported by glycerol phosphate and succinate and weakly inhibited 45Ca uptake supported by the other substrates. These results suggest that diazoxide, although not completely specific, is predominately an inhibitor at site II of the respiratory chain. This result is consistent with previous work that showed diazoxide inhibits the enzyme activity of the mitochondrial glycerol phosphate dehydrogenase in islets. Sodium ion inhibited the net accumulation of 45Ca by islet mitochondria suggesting a similarity between islet mitochondria and those of heart and some other endocrine tissues.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0158-5231
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
771-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The use of calcium uptake by small amounts of mitochondria from pancreatic islets to study mitochondrial respiration: the effects of diazoxide and sodium.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't